About Multiple Sclerosis, simvastatin, and other statins treatments
Simvastatin has been mentionned as a possible treatment for Multiple Sclerosis. Here we provide some links to relevant studies on the topic.
First an article gathered by ScienceDirect in the Lancet about oral simvastatin and RRMS results seem promising, but the article is dated 2004
Another, more recent study mentionned in ScienceDaily Statins May Have A Negative Impact In Multiple Sclerosis Patients, is negative. Quoting
"….The results of our study indicate that simvastatin has in fact, a slightly deleterious effect on myelin under non-pathological conditions, adds Dr. Miron…."
However, a UCSF study posted in Eurekalert, claims Statins may slow progression of multiple sclerosis ……..
So what is an MSer to think?
Seems to us the jury is still out, but, as always, talk to your doctor….
Categories: Multiple Sclerosis, Uncategorized, autoimmune diseases Tags: Multiple Sclerosis, simvastatin, statins, Treatments
Evidence for a two-stage disability progression in multiple sclerosis (pubmed)
MediNewsDigest: According to this study there are two distinct phases with MS, not to be confused with the usual categories of relasing-remitting or progressive. Those phases seem to have more to do with disability levels. Pubmed , Brain 2010 Jul;133(Pt 7):1900-13. Epub 2010 Apr 27).
Categories: Multiple Sclerosis, autoimmune diseases Tags: Brain, CareResourceGuide, disability, medinewsdigest, MS, Multiple Sclerosis, progression, pubmed, two-stage
Glatiramer acetate [Copaxone] exposure in pregnancy: preliminary safety and birth outcomes (sciencedirect)
MediNewsDigest:: Quoting the sciencedirect article:
"….our early experience suggests that when considering the risks and benefits of treatment withdrawal prior to pregnancy, it may be reasonable to continue GA in those patients with previously highly active disease…." A soft, provisional, safety conclusion for the use of copaxone during pregnancy.. More data needed.
Categories: Multiple Sclerosis, Uncategorized Tags: birth, CareResourceGuide, Copaxone, exposure pregnancy, Glatiramer acetate, medinewsdigest, preliminary, Safety, sciencedirect
Multiple Sclerosis: Natalizumab [Tysabri] induces a rapid improvement of disability status and ambulation (pubmed)
MediNewsDigest: Clearly the research team liked Natalizumab (Tysabri).
Quoting:
“…Sixty-two per cent of patients showed no clinical and no radiological signs of disease activity, and 29% showed a rapid and confirmed EDSS improvement over 44 weeks of natalizumab therapy…. A clinically meaningful improvement in ambulation speed was observed in approximately 30% of patients…”
Translating: 62% were stabilized,and 30% improved. This is over 44 weeks. Short term in our book, what is needed now is medium to long term evaluation. say 5-10 years? The risk of PML ( progressive multifocal leukoencephalopathy) has been accepted by the FDA as just that, a risk. At that point, it is the warning is only for legal purposes, since it does not cover a specific subset of MSr’s. CLICK HERE for link to article.
However, Bloomberg reports that Biogen is working on a test to determine just who among MS patients is most at risk of PML, CLICK HERE for bloomberg
Categories: Multiple Sclerosis, Uncategorized, autoimmune diseases Tags: ambulation, CareResourceGuide, disability, improvement, medinewsdigest, natalizumab, pubmed, rapid, Tysabri
Categories: Multiple Sclerosis, Musculoskeletal Diseases, Uncategorized, autoimmune diseases Tags: ambulatory persons, bone, CareResourceGuide, low, medinewsdigest, mineral density, Multiple Sclerosis, predictors, prevalence, pubmed
Categories: Multiple Sclerosis, Uncategorized, autoimmune diseases, spasticity Tags: CareResourceGuide, dependency, medinewsdigest, Multiple Sclerosis: Severe, paraspasticity, pubmed, Spasticity, zolpidem
Categories: MS Multiple Sclerosis, Multiple Sclerosis, autoimmune diseases Tags: Advances, CareResourceGuide, medinewdigest, Multiple Sclerosis, research, treatment, WebMD
Acoustic Device Heals Pain? (ABCNews,youtube)
MediNewsDigest: Medsonics Device: Real or Hoax? But worth following….
Categories: Multiple Sclerosis, neuroscience, pain Tags: ABCNews, Acoustic Device, CareResourceGuide, Heals, medinewsdigest, medsonics, pain, youtube
Categories: Crohn's disease, Multiple Sclerosis, Uncategorized, autoimmune diseases Tags: Biological agents, CareResourceGuide, Crohn's disease, human polyomavirus, medinewsdigest, reactivation, risk, sciencedirect, sjcrg
Gender Issues in Fibromyalgia and Autoimmune Diseases such as Multiple Sclerosis
SJCRG: CLICK HERE for an interesting article about Men and Fibromyalgia.
SJCRG: CLICK HERE For discussion on the ratio of women to men for auto immune diseases. essentially 4:1
By the way, is this just a coincidence or is fibromyalgia an autoimmune disease too?
